Bio Pharma

Accelerate your vaccine research CRM-197 from Lorven Biologics


  • CRM197 is a detoxified Diphtheria toxin, which is a widely used carrier protein for protein-polysaccharide conjugate vaccines.
  • CRM197 is used as the carrier protein for Menjugate, Menveo (Novartis), Prevnar, HibTITER (Wyeth), Synflorix (GlaxoSmithKline) and PCV15 (Merck), etc.

Salient features of CRM197 from Lorven Biologics

  • Conjugation ready Carrier protein CRM-197 from Bacillus host.
  • 96.0% pure, available at an economical price.
  • Lorven’s CRM197 is expressed in our proprietary bioengineered Bacillus subtilis expression system.
  • Direct secretion of active CRM197 into the growth media. 
  • Endotoxin free secretion system.
  • Fully functional native conformation.
  • Yields up to gm/lit/hour.
  • Reduced production cost and time to market.

Product Quality

  • Biologically identical to native CRM197.
  • 100% native conformation.
  • High immunogenicity as a carrier with Vaccine.
  • Free from animal-derived components.


  • Bacillus subtilis: Genetically  highly  amenable  host  organism with BSL-1 maintenance.


  • Indian Patent Application No: 201741031140
  • Title: Process for improved protein expression of biologically active CRM197 in Bacillus subtilis by strain engineering.